Abstract
Author(s): M. Anitha, Divya.G, DM. Monisha, J.Hema Priya, A. Mohammedsulthan
Often hailed as a revolutionary new technology, Nanotechnology has the potential to impact almost every area of the society. One area in nanotechnology that holds promising great benefits for the society in future and is in the realm of medicine is Nanomedicine.Among which comes our core of the study Silver Nanoparticles which has shown great affirmation in terms of biomedical applications, not only due to their large surface area to volume ratio, but also because they exhibit different biomedical activities.Antibacterial efficacy of Silver nanoparticles synthesized from the extract of guava fruit (Psidium guajava) were tested against multi drug resistant strains of Gram negative bacteria isolated from diabetic foot ulcer patients by agar well diffusion method. Antibacterial activities of the silver nanoparticles were compared with the conventionally used antibiotics. Silver nano particles showed maximum inhibitionagainst MDR strains Pseudomonas aeruginosa,E.coli, Klebsiella pneumoniae,Proteus mirabilis and Acinetobacter baumannii.The aim of this invitro study is to examine the efficacy of silver nanoparticles in treating bacterial infections from diabetic foot ulcers patients.The findings implicating that the silvernanoparticles have effective antibacterial actions than the commonly used antibiotics.We conclude, silver nanoparticles are now considered a viable alternative to antibiotics and seem to have a high potential to solve the problem of the emergence of bacterial multidrug resistance on diabetic foot ulcer infections
