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Author(s): Ruby Philip*, 2G. Pratheesh

A simple, sensitive, specific spectrophotometric method has been developed for the determination of Quetiapine fumarate in pure form and in pharmaceutical formulations. Quetiapine fumarate exhibited maximum absorption at 278nm and obeyed Beer’s law in the concentration range of 10-80μg/ml. LOD was found to be 10.3 X 10-2and LOQ was found to be 18.9 X 10-2. The regression equation was found to be y = 0.1892x + 0.0037. The sample solution was stable for 24hrs. The assay procedures showed good agreement with label claim. The proposed method was found to be simple, precise, specific and quick for routine quality control.

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Citations : 440

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