Author(s): C. Senthil Kumari *1, V. Vaidhya Lingam2, A. Babu Thandapani3
The present study was aimed to evaluate the effect of Mirabilis jalapa Linn on anti-implantation activity of female albino Wistar rats. The animals were treated with ethanolic extract of Mirabilis jalapa, with doses of 200 mg and 400 mg/kg body weight from day 1 to day 7 of pregnancy. The rats were sacrificed on day 10 of pregnancy. Presence of foetus, implantation sites and number of corporal lutea were recorded. There was a 100% reduction in pregnancy was observed in 400 mg/kg of Mirabilis jalapa and it showed maximum percent inhibition or reduction when compared with control. All the rats were delivered in control groups, where as 30% of rats delivered in 200 mg/kg of Mirabilis jalapa Linn when compared to control. Biochemical changes were observed in Blood Glucose, Cholesterol, triglycerides. In 400 mg/kg of Ethanolic Extract of Mirabilis jalapa Linn showed depletion in Blood Glucose, Cholesterol, Triglycerides when compared with control. In 200 mg/kg it showed less depletion of blood glucose, Cholesterol and Triglycerides when compared with control.