Author(s): Natarajan Kiruthiga*, Thangavelu Prabha, Chellappa Selvinthanuja, Kulandaivel Srinivasan and Thangavel Sivakumar.
The aim of the present research work was to design, synthesize ten hybrids of flavones and determination of its structure by various spectroscopic techniques such as FT-IR, GCMS and 1HNMR. The synthesized compounds were subjected for insilico studies on multi-targeted diabetic enzymes such as Aldose reductase, protein tyrosine phosphatase and alpha amylase. Over all docking score afforded that alpha amylase possess potential inhibition than the existed enzymes in the range of -7.18 to -9.81 Kcal/mol compared with their standard Acarbose (-7.61 Kcal/mol). Based on that, hybridized flavones were screened for invitro anti-diabetic activity by alpha amylase inhibitory assay. The invitro result was well correlated among the docking score and confirmed the anti-diabetic property of titled compounds. From which the compound HFa-HFc, with hydroxyl substitution on ring A showed noteworthy IC50value compared with their standard Acarbose. This study summarized that the hybrids of flavones were pilot molecule for anti-diabetic activity