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Author(s): K. Lakshmi1, P.Srinivas2, A. Srikanth2and K. Seshaiah1,*

A simple and sensitive methodfor the determination of curcumin sulphate, in human plasma by High Performance Liquid Chromatography coupled with mass spectrometry method has been developed and validated. Nevirapine is used as an internal standard. Analyte and internal standard were extracted with ethyl acetate and isopropyl alcohol from human plasma, separated on a Zorbax Eclipse plus c18150, 4.6mm, 5μm column. An AB MDS SCIEX 4000 Q trap mass spectrometer was used under multiple reaction monitoring mode (MRM) for quantification oftransitions at m/z 447.20, 134.00 and 265.10, 182.00 under negative ion mode for curcumin sulphate and nevirapine respectively. The intra and inter batch precision and accuracy studies were well within the acceptance limits. The linearityof curcumin sulphate was shown in the range of 25-10000.00ng/ml with 85-115% accuracy and < 20% precision in human plasma. The method has been proved to be simple, sensitive, fast, reliable, rugged and reproducible. The validated method can be applied for the estimation of curcumin sulphate in plasma samples for pharmacokinetic studies.

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Citations : 440

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