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Author(s): Mrityunjay Banerjee*, Tejaswani Dash, Swapneswar Khatua

A Simple UV-Spectrophotometric method was developed for the estimation of Anastrozole in bulk and tablet dosage form by using 1N HCl. The maximum absorbance (λmax) was found to be 205.9 nm. The calibration curve was in concentration range 8-18 μg/ml with correlation co-efficient of 0.999. The procedure was validated as per ICH rules for accuracy, precision, detection limit, linearity, reproducibility and quantitation limit. The percentage recovery for Anastrozole was found to be 99.80% to 100.10 %. Due to its simplicity, rapidness, high precision and accuracy of the method it may be used for determining Anastrozole in bulk and tablet dosage form.

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Citations : 440

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