Abstract
Author(s): Gajanan A Vaishnav, Sushama Vaishnav-Hota, Shital Godse, Angadi S.S. and Patil S. J.3
An accurate, precise and simple spectrophotometric method for the determination of Terbutalin sulphate based on the formation of a yellow color product with Ninhydrin in the presence of sodium bicarbonate with an λmax at 346 nm. The Reaction heating temperature was 80°C for 30 min. The calibration curve was linear over the range of 10-60 µg/ml and the regression equation obtained was y=0.0263x+0.2 with a regression coefficient (r) of 0.98 (n=10). The limit of Detection (LOD) and limit of Quantification (LOQ) calculated as per ICH guidelines were 18.15µg/ml and 55µg/ml, respectively
