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Dual Spectrophotometric Estimation of Paracetamol and Meloxicam in Bulk and its Pharmaceutical Dosage Form by Simultaneous Equation Method


Author(s): S. K. Sahu, Md. Afzal Azam, A. K. Samantaray, M. Banarjee and G. K. Sahu

A simple and sensitive UV spectrophotometric method has been developed and subsequently validated for the simultaneous estimation of paracetamol and meloxicam in bulk and pharmaceutical formulations. Borate buffer (pH 9.0) was used as a solvent in the present investigation. Quantitative measurements were made at 256.8 - and 268.8 nm for paracetamol and meloxicam respectively. The method was validated over the range of 10 to 90 ?g/ml for paracetamol and 1 to 16 ?g/ml for meloxicam with a correlation coefficient (r2 ) 0.999. The method was shown to be accurate and precise with inter-day and intra-day percent relative standard deviation values in the range 0.051 to 0.281 and 0.033 to 0.295 for paracetamol and 0.527 to 0.952 and 0.344 to 0.620 for meloxicam. The percent recoveries were found to be 99.95 to 99.99 for paracetmol and 99.24 to 100.45 for meloxicam. The limit of detection and limit of quantification was 0.010 and 0.036 ?g/ml for paracetamol and 0.017 and 0.056?g/ml for meloxicam. The method has been successfully utilized for simultaneous estimation of paracetamol and meloxicam in tablets and can be extended for the routine analysis in bulk drugs.

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