Abstract
Author(s): Arpan Bhardwaj1, Pervaz Ahmad Ganie
Green and efficient protocol is designed and implemented for the synthesis of biologically active derivatives of pyrimidopyrimidine promoted by the use of an effective and green ionic liquid TEAA, as a catalyst and solvent. Multi-component one-pot condensation reaction of aryl aldehyde, barbituric acid and urea/thiourea resulted in high yield of pure products in short reaction time in presence of TEAA catalyst is carried out and finally catalyst is easily recovered and reused for many trials. The structural features of new derivatives were characterized by IR, 1HNMR, 13CNMR, Mass spectroscopic techniques. All newly synthesized compounds were evaluated for anti-bacterial activities against gram +ve bacteria and gram –ve bacteria and anti-fungal activities using disc diffusion method.
