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Author(s): Bhansali Sarika Rameshlal, Patil Pravin B., Kalkotwar R.S.

Hot-melt technology is a process in which molten excipient(s) and/or drug are either layered on substrate, congealed alone or with excipient(s) using different technologies. Hot-melt technology is used to design various dosage forms and drug delivery systems which fulfil the therapeutic needs of the patient, which are cost-effective and manufactured by eco-friendly process. Hot-melt technology is used to enhance the bioavailability of poorly water soluble and lipophilic drugs, taste masking of bitter drugs, fabrication of extended release multiparticulates and designing of micropellets for compaction. This paper reviews the innumerable benefits of hot melt technology, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.

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Citations : 440

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