Abstract
Author(s): Kaki Soujanya, K Kranthi Raj and D Ramachandran
The main ground for nosocomial deaths around the world wasGram Staphylococcus aureus sortase A was main target which was involved So computational docking models were developed to screen the in house database consists of 1500 molecules. 4 amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitri phenyl-1H-pyrazol-5(4H)-one (DRC-KS2) were identified as novel molecules that can inhibit Staphylococcus aureus sortase A. Docking score of DRC-KS1 and DRC-KS2 was -4.32 and concentration against Staphylococcus aureus sortase A. DRC These molecules were proved potent and can be used as lead mole Keywords –Docking, Synthesis, Sortase A, Minimum inhibitory concentration ese molecules were proved potent and can be used as lead molecules in the drug discovery pipeline
