Author(s): Shashirekha Kanathala*, Manish Gangrade, Kavita Bagwe, Deepti Sane
The combination of Lopinavir and Ritonavir is used with other medicines to treat Human Immuno-Deficiency Virus (HIV) infection. Lopinavir and Ritonavir exist in different crystallographic forms known as polymorphs. Since the polymorphic forms differ in their solid-state structure, they can have different aqueous solubilities and dissolution rates. According to literature survey, none of the currently available methods is helpful in the identification of crystalline forms of Lopinavir and Ritonavir. Hence, a cost-sensitive, rugged, non-destructive and environment friendly Horizontal Attenuated Total Reflectance - Fourier Transform Infrared (HATR-FTIR) Spectroscopic method has been developed and validated which can be used for routine quality control and stability analysis.