News

Articles related to COVID-19 will be published in special issue.

Articles Statistics
48.6% 14.5%
Pharmaceutics
Manuscript Statistics
12.5% 21.9% 46.9%
Withdrawn

INVESTIGATION OF ANTIMICROBIAL PEPTIDE ACTIVITY AGAINST AMASTIGOTE FORMS OF LEISHMANIA MAJOR


Abstract

Author(s): Mojtaba Esmailpour Roshan*

Zoonotic cutaneous leishmaniasis caused by Leishmania major is the most common type of disease in Iran. Conventional anticoagulants have been used in the treatment of cutaneous leishmaniasis for a long time, but drug resistance and some serious side effects have been reported. Therefore, the discovery and development of new therapeutic candidates is needed. Peptide CM11 is one of these peptides whose antibacterial activity has been proven. This peptide is a short cecropin-melittin hybrid peptide obtained through a hybrid sequencing method. The aim of this study is to evaluate the anti-leishmanial activity of CM11 platelets against amastigote forms of Leishmania major. In this research, amastigote forms of Iranian garlic L. major (MRHO/IR/75/ER) were cultured in the presence of different molar concentrations of methylantimony (glucanthium) to find the most suitable concentration of glucanthium in comparison with L. major amastigotes, then the anti-leishmania activity Different concentrations of CM11 peptide (8, 16, 32 and 64 μM) for 24, 48 and 72 hours were examined by DAPI staining. In addition, MTT was used to determine the cytotoxic effects of CM11 peptide on mouse fibroblast cells. The results showed that CM11 peptide has an antimicrobial effect against the Iranian isolate of L. major in laboratory conditions. CM11 peptide seems to have significant potential as a new anti-leishmanial agent.

Indexed in

Google Scholar

Chemical Abstract Services (CAS)

Science Central

Index Copernicus

Pharmaceutical Science Open Access Resources (PSOAR)

Rubriq

Directory of Research Journals Indexing

Journal Seeker

Directory of Science

Indian Science.in

Jour Informatics and China Knowledge Research Integrated (CNKI)

EBSCO

Publication Statistics
Vol... Vol... Vol... Vol... Vol... Vol... 0 5 10 15 20 Issues No.of Articles
6
World wide visitors
pharmaceutical analysis, international journal, chemical and pharmaceutical, journal of chemical, online open access journals, open access journals
Google Scholar citation report
Citations : 440

International Journal of Chemical and Pharmaceutical Analysis received 440 citations as per google scholar report

International Journal of Chemical and Pharmaceutical Analysis peer review process verified at publons

Indexed In