News

Articles related to COVID-19 will be published in special issue.

Articles Statistics
48.6% 14.5%
Pharmaceutics
Manuscript Statistics
12.5% 21.9% 46.9%
Withdrawn

In-vivo Antioxidant Enzyme Activities of Eupatorium Adenophorum (Sticky Snakeroot) Leaf Extract


Abstract

Author(s): Y. Damodar Singh

Twenty Swiss albino mice (male) randomly divided into four groups were administered orally with vehicle (5% Tween 80), 1/20th (i.e. 175 mg/kg), 1/10th (i.e. 350 mg/kg) and 1/5th (i.e. 750 mg/kg) LD50 doses of methanolic leaf extract of Eupatorium adenophorum respectively; for a period of 90 days and the levels of various antioxidant enzymes such as lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) were studied. Treatment of the mice with methanolic extract of E. adenophorum at the dose levels of 350 and 750 mg/kg revealed marked increase in lipid peroxidation (LPO) levels and decreased activities of superoxide dismutase (SOD) as compared to control and mice treated with 175 mg/kg, while all the treated animals showed significant reductions in catalase (CAT) and glutathione (GSH) activities as compared to control. The present findings suggest that methanolic leaf extract of E. adenophorum may be having dose dependant hepatotoxic effect on mice as it markedly induced lipid peroxidation and reversed the activities of the antioxidant enzymes.

Indexed in

Google Scholar

Chemical Abstract Services (CAS)

Science Central

Index Copernicus

Pharmaceutical Science Open Access Resources (PSOAR)

Rubriq

Directory of Research Journals Indexing

Journal Seeker

Directory of Science

Indian Science.in

Jour Informatics and China Knowledge Research Integrated (CNKI)

EBSCO

Publication Statistics
Vol... Vol... Vol... Vol... Vol... Vol... 0 5 10 15 20 Issues No.of Articles
6
World wide visitors
pharmaceutical analysis, international journal, chemical and pharmaceutical, journal of chemical, online open access journals, open access journals
Google Scholar citation report
Citations : 440

International Journal of Chemical and Pharmaceutical Analysis received 440 citations as per google scholar report

International Journal of Chemical and Pharmaceutical Analysis peer review process verified at publons

Indexed In