Author(s): Nilesh Gorde, Mohan Kale, Sandeep Waghulde, Pravin Naik
Therapeutic effect depends upon the bioavailability of the drug which in turn depends upon the solubility and dissolution rate. A solubility problem is a major challenge for the pharmaceutical industry with developments of new pharmaceutical products. There are various techniques but liquisolid compact is a new and promising method that can change the dissolution rate of water insoluble drugs. According to the concept of liquisolid systems water-insoluble drugs dissolved in suitable non-volatile solvents, may be transformed into free-flowing and readily compressible powders by a simple admixture with excipients referred to as the carrier and coating materials. Compared to conventional tablets, rapid disintegration rates are observed and therefore, they confirm improved release rates in addition to greater bioavailability. The use of nonvolatile solvent in the formulation causes increased wettability of water insoluble drugs and ensures molecular dispersion of drug in the formulation. Modification of formulation by use of certain agents cause sustained release of drugs from the liquisolid tablets. Hence Liquisolid compacts containing water-insoluble drugs expected to display enhanced dissolution characteristics and consequently improved oral bioavailability.