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Author(s): Sita Kumari Karanam, Soudamini Alekhacharan and Venkata Padmini Madem

A simple, rapid, specific, accurate and economic UV spectrophotometric method has been developed using methanol as solvent to determine the Domperidone Maleate (DOM) tablet dosage formulations. At a pre-determined λmax of 285.9 nm, it was proved that the developed method obeyed Beer-Lambert’s law in the concentration range of 10-60μg/ml having line equation y = 0.040x + 0.365 with correlation coefficient of 0.998. There is no interference from any common pharmaceutical excipients. The precision of method was determined by performing repeatability study, intra-day study and inter-day study. The accuracy of the method was confirmed by recovery studies from tablets at three different levels of standard additions. Results of the analysis were validated statistically and by recovery study. The analytical method was validated for various parameters as per ICH (International Conference on Harmonization) guidelines.

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Citations : 440

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