Abstract
Author(s): P. Vasubabu, C. Aiswarya, K. V. R. L. Sridevi, M. Bhuvanasri, P. Sindhura, T. Mounica
A simple, rapid, accurate, precise, and economic spectrophotometric method for simultaneous estimation of paracetamol and diclofenac in tablet dosage form have been developed and validated. Paracetamol and diclofenac show absorbance maximums at 242 and 273nm respectively by using 6.8 phosphate buffers, so absorbance was measured at the same wave lengths for the estimation of paracetamol and diclofenac. Absorbance is measured at 240.2 nm (Isoabsorptive point) and 258.4nm (λmax of diclofenac). Both drugs obey the Beer’s Lambert's law in the concentration range of 10-30 µg/mL. Methods are validated according to ICH guidelines and can be adopted for the routine analysis of paracetamol and diclofenac in tablet dosage form
