Author(s): Pasupuleti Sunitha*, Sangisetti Priyanka, Thudimilla Supriya
A validated RP-HPLC method has been developed for the determination of Indinavir sulphate capsule dosage form. This method is developed by using a Zodiac ODS hypersil C18column (250mm length, 4.6mm internal diameter and 5μm particle size) and a mixture phosphate buffer pH 5.5, Acetonitrile and Methanol (50:30:20) as a mobile phase. The drug was quantified by a UV detector at 260nm.The method is linear in range of 48μg/ ml to 112μg/ ml. The accuracy of the method was found to be in the range of 98.36% to 101.74%. The proposed method was found to be linear, precise, and accurate for the quantitative estimation of Indinavir sulphate in capsules and can be used for commercial purpose.