Author(s): Preeti S. Zade and M.M.V. Ramana
Microwave irradiation is well known for its ability to reduce reaction times dramatically, to increase product yields, and to enhance product purities by reducing unwanted side reactions compared with conventional heating. Many marine alkaloids are known which have a common structural feature of tetracyclic pyrido [2,3,4-kl] acridine system. Most of these molecules exhibit very interesting biological properties like antitumor, cytotoxic and antiviral activities. This is due to their interesting biological activities and challenging structures. We report a simple and convenient synthesis of pyrido [2, 3, 4-kl] acridine utilizing microwave irradiated intramolecular nitrene insertion reaction as key step for generating the tetracyclic framework of marine alkaloids.