Author(s): Sitaram Atmaji Naik*, E.V.S. Subrahmanyam, Paramita Das, A.R. Shabaraya
Two simple, accurate, precise, reproducible and an economical spectrophotometric method were developed for the simultaneous estimation of Ramipril (RAM) and Metoprolol Succinate (METO) in pharmaceutical bulk and synthetic mixture. The first method was developed on the basis of Q-absorbance ratio method for analysis of both the drugs. Wavelengths selected for analysis in Q-absorbance ratio method were 205nm (λmax of Ramipril) and 243nm (iso-absorptive wavelength) in methanol. Ramipril and Metoprolol Succinate were found to be linear over the range of 3-30μg/ml and 20-200μg/ml respectively. It could be concluded from the results obtained in the present investigation that the method for the simultaneous estimation of Ramipril and Metoprolol Succinate in tablet dosage form are simple, rapid, accurate, precise and economical and can be used, successfully in the quality control of pharmaceutical formulations and other routine laboratory analysis.