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NEW UV SPECTROPHOTOMETRIC METHOD FOR DEVELOPMENT AND VALIDATION OF VALGANCICLOVIR HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS


Abstract

Author(s): Karthik K., Jose Gnana Babu C., Sowyma H. G.

A simple, sensitive, and economical UV spectrophotometric method has been developed for the estimation of Valganciclovir in bulk and pharmaceutical dosage form. Validation study was performed to develop a simple, sensitive, rapid, accurate, and economical UV spectrophotometric method for the estimation of Valganciclovir hydrochloride. UV 1800 double beam UV visible spectrophotometer with the pair of 10 mm path length matched Quartz cells were used for the study. Valganciclovir shows the maximum absorbance at 252 nm. Hence the area under the curve was measured at 247 nm and 257 nm, respectively. The linearity was measured at the concentration range of 1-6 µg/ml with the correlation coefficient of 0.9994. The regression equation was found to be Y=0.0354 x-0.0041. The standard plot clearly shows a straight line passing through the origin. The limit of detection and the limit of quantitation were found to be 0.0522 μg/ml and 0.1589 μg/ml, respectively. The results of analysis were validated according to the ICH guidelines and by recovery studies are found to be satisfactory. The above method was applied to pharmaceutical dosage forms successfully

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