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Author(s): Niharika Kondepudi, Jeevan Kumar Jalasuthram, Aparna Tatavarthy

Aceclofenac is a phenyl aceticacid derivative with potent analgesic and anti inflammatory properties and an improved gastro intestinal tolerance. In the present study, a Reverse Phase HPLC method and FTIR methods were developed for the analysis of Aceclofenac for related substances and concordance with the standard. Both the methods showed excellent sensitivity with 0.008% total impurities and the sample spectrum is 99.89% concordant with that of standard aceclofenac . This sensitive and selective method can be used for detection of related substances in aceclofenac in order to control and regulate process related impurities.

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Citations : 440

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