Author(s): Dhwani Shah, Kunjal Vegad, Ekta Patel, Jigna Prajapati, Kaushik Patel, Yogesh Patel
A simple, accurate, rapid, economical UV spectrophotometry method namely Absorption ratio, and RP-HPLC method have been developed and validated for estimation of Amoxicillin and Probenecidin combined tablet dosage form and can be used in routine analysis. In Absorbance ratio method absorbance measured 228nm and at Iso-absorptive point 237 and correlation coefficient was found to be 0.9971,0.9968 and 0.998,0.998 for Amoxicillin and Probenecidat 228nm and 237nm respectively. Mean assay was found to be 99.51251% and 98.93545% for Amoxicillin and Probenecid respectively by Absorption ratio method. Both the methods were found to be linear in the concentration range of 2-14μg/ml for Amoxicillin and 2-14μg/ml for Probenecid.