A high-performance liquid chromatographic and UV spectrophotometric method were developed and validated for the quantitative determination of three anti-hypertensive drugs viz. Metoprolol succinate, Telmisartan and Cilnidipine in pure bulk and tablet dosage form. The different validation parameters such as linearity, precision, accuracy and specificity, limit of detection (LOD) and limit of Quantification (LOQ) were determined according to the International Conference on Harmonization ICH Q2 guidelines. The UV spectrophotometric determinations were performed at 224 nm, 299 nm, and 242 nm for Metoprolol succinate, Telmisartan, Cilnidipine respectively. Chromatography was carried out by isocratic technique on a reversed-phase Luna C18 phenomenix column (250 mm × 4.6 mm × 5 μm) thermo stated HPLC column with Acetonitrile and water (90:10) as mobile phase based and optimized depending on the polarity of the molecules. The linearity of the calibration curves for each analyte in the desired concentration range is good (r2>0.999) by both the HPLC and UV methods. Moreover, the accuracy and precision obtained with HPLC correlated well with the UV method which implied that UV spectroscopy can be a cheap, reliable and less time consuming alternative for chromatographic analysis. The proposed methods are highly sensitive, precise and accurate and hence were successfully applied for the reliable quantification of API content in the commercial formulations of Metoprolol succinate, Telmisartan and Cilnidipine.