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Simultaneous Estimation of Telmisartan and Indapamide in Tablet Dosage Form by RP-HPLC Method and its Method Validation


Abstract

Author(s): Alagar Raja, Bhargav Kumar.S, Muthu Kumar, David Banji, Anil Kumar, Bhavani

A new simple, accurate, rapid and precise isocratic RP-HPLC was developed and validated for the determination of Telmisartan and Indapamide in Pharmaceutical tablet dosage form. The Method employs Shimadzu LC system on Symmetry C8 (4.6 x 150mm, 3.5µm, Make: X Terra) and flow rate of 1ml/min with a load of 20µl. Potassium Dihydrogen Orthophosphate buffer and Acetonitrile was used as mobile phase in the composition of 43:57 v/v. The Detection was carried out at 254 nm. Linearity ranges for Telmisartan and Indapamide were 200-600µg/ml and 9-22.5µg/ml respectively for HPLC. Retention Time of Telmisartan and Indapamide were found to be 2.2 & 5.8 min respectively. Percent Recovery study values of Telmisartan and Indapamide were found 100.56 % and 99.4 % respectively. This newly developed method was successfully utilized for the Quantitative estimation of Telmisartan and Indapamide in tablet dosage form. This method was validated for, linearity, precision, Accuracy, System suitability Robustness, Ruggedness as per ICH guidelines.

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