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Author(s): Drasti Mukeshsinh Parmar, Madhuri Hinge, Khyati Khalpa Dhodi

The present work was focused at development of a novel and validated technique for solubility enhancement by principle of hydrotropic method for low soluble anti anginal drug ranolazine in pure form. It was estimated using UV spectrophotometry at 268 nm and hydrotropic agent urea (6 M) has no interference with drug estimation. The % Recovery for the ranolazine drug at the 268 nm was found to be 99-100.20 %. Linearity for ranolazine was found to be in range of 10-100 mg/ml (Y = 0.004x +0.066, R2 =0.999). Limit of detection was found to be 0.4760 mg/ml and Limit of quantification was found to be 1.4425 mg/ml. The results showed that there was an increase in the solubility of ranolazine with hydrotropic method compared to pure drug in distilled water. There was 8.390-fold enhancement in aqueous solubility of ranolazine with urea as a hydrotropic agent. In order to elucidate the interaction, a UV spectrophotometric method was developed is simple, economical, accurate and validated by using urea 6 M as a hydrotropic agent.

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Citations : 440

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