Author(s): S. B. Ghodile, P. T. Kosankar, R. D. Raut
A series of diversely substituted Pyrazole derived quinoline (4a-g) were obtained by the reaction of various chalcones (3a-g) with hydrazine hydrate. New compounds were characterized by FT-IR, 1H- NMR and Elemental analysis. Antibacterial and antifungal activities of those compounds were determined by disc diffusion method against A. niger, A. flavus (fungal strains), E. coli and P. aeruginosa (Gram negative bacteria), S. aureus and S. pyogenes (Gram positive bacteria) using Nystatin (for fungi) and ciprofloxacin (for bacteria) as a standard drugs. The in vitro antifungal and antibacterial screening of the pyrazole derived quinoline (4a-g) revealed that most of the compounds in the series showed potent activity.