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Author(s): Poonam Gupta*, Jitendra K. Gupta, Shivani Bansal, A. K. Halve and Apoorva Gupta

Pyrazolone Schiff base derivatives are an important class of heterocyclic compounds that occur in many drugs and synthetic products. It has a particular value due to their broad spectrum of biological activities and their utility as synthetic tools in the design of various bioactive molecules. It is also exhibited analgesic, antipyretic and anti-inflammatory activity. In the present study, a series of (5E)-3-methyl-N-substitutedphenyl-5-[(4-sulfamoylphenyl)imino]-4,5-dihydro-1H-pyrazole-1-carbothioamide (5a-g)were synthesized by the reaction of pyrazolone and sulfanilamide in ethanol. The synthesized compounds were characterized on the basis of IR, 1H-NMR, 13C-NMR and elemental analysis. All synthesized Compounds were screened for antimicrobialactivities using disc diffusion technique against two bacterial pathogens viz Staphylococcus aureusand Pseudomonas aeruginosaandtwo fungal pathogens namely Candida albicanes, Aspergillus niger. Chloramphenicol and Fluconazole were used as standard drug respectively. The compounds exhibit moderate activity.

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pharmaceutical analysis, international journal, chemical and pharmaceutical, journal of chemical, online open access journals, open access journals
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Citations : 440

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