Abstract
Author(s): Lincy Joseph, Mathew George, Vineeta Arya, Anju.V
Medicinal plants are highly esteemed over the world as a key source for the discovery of new drugs. The isolation or extraction of new drugs or lead molecules from natural products have facilitated a great extend to drug discovery. The study mainly aim to isolate oleanolic acid and their derivatives from the plant sources and the derivatives of the compounds were synthesized and characterized so that in future they can be developed as drug moieties for their physiological activities. The triterpenoid compounds like oleanolic acid, were extracted from the medicinal plant Lanata camara by Vacuum Liquid Chromatography. The fractions obtained during the isolation were pooled on the basis of their TLC profile. The derivatives of oleanolic acid were prepared by acetylation, esterification and amidation reaction at the C-28 position of oleanolic acid. The compounds were characterized using various spectroscopic methods .15 derivatives of oleanolic acid were synthesized and characterization of each of the compound for the identification were carried out using 13C and proton NMR techniques. The NMR profile revealed that all the synthesized compounds were active and can function efficiently for their pharmacological activity
