Author(s): Rohini RM, Prakash KJ
The various pharmacological properties of chalcones has instigated us to synthesis and study antitubercular antimicrobial and anti inflammatory activity. Following Claisen-Schmidt condensation reaction, chloroacylaminochalcones (4a-b) were obtained by the reaction of chloroacetylamido acetophenone with substituted benzaldehyde, treatment of (4a-b) with substituted amines yielded the desired compound. Structures of synthesized compounds were established by spectral data’s. Antitubercular activity was determined by Microplate Alamar Blue Assay Method against M. tuberculosis H37 RV and in vitro anti inflammatory study was conducted by bovine serum albumin assay method. Except 5c compound all have shown anti tubercular effect at 100 µg /ml and 50 µg /ml,and were sensitive to microbial strains used and inhibition denaturation of protein was observed at 10 µg /ml.