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Author(s): Kirankumar S. V., Jose Gnana Babu C., Sowmya H. G.

A new and simple Area under curve spectroscopic method was developed and validated for the estimation of Cefadroxil in bulk and pharmaceutical dosage forms and Area under curve was measured at 257-267nm in 0.1N Hydrochloric acid. The linearity was found to be in the concentration range of 2-10 µg/ml and the correlation coefficient was found to be 0.9997 and it has showed good linearity, reproducibility, precision in this concentration range. The regression equation was found to be Y=0.0342X +0.0008. The % recovery values were found to be within the 99.79-100.9% and showed that the method was accurate. The LOD and LOQ were found to be 0.085 and 0.255 µg/ml, respectively. The % RSD values were less than 2. The present method is accomplishing the validation parameters according to ICH guidelines. The developed method was successfully applied for the quantitative estimation of Cefadroxil in bulk and pharmaceutical dosage forms.

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Citations : 440

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