Author(s): Aruna Bhatia, Mansimran Kaur Randhawa, Manpreet Kaur
The in depth studies on the immune response shows its application in diseases other than infections. There are hardly any chemical based drugs which are given as immunomodulators. Most of the disease treatment drugs available in the market may have side effects and are costly. Hence, alternatively the immunotherapy can be employed to manage immune related diseases by the use of natural agents like probiotics. Moreover, the literature shows that prokaryotic DNA can activate immune response and has potential therapeutic applications. This immune efficacy of DNA is due to the presence of unmethylated DNA i.e. CpG motifs (regions of DNA where Cytosine and Guanine are separated by only one phosphate) in prokaryotes. Hence, the various applications of prokaryotic as well as probiotic DNA are being explored in the treatment of immune related disorders. The status of Probiotic DNA and synthetic oligodeoxynucleotides containing CpG motifs (CpG-ODNs) from various microorganisms are reviewed here, with reference to some key examples where these have succeeded in prevention and treatment of diseases.